Part Three of our Microdosing Mushroom Series- Honest Discussion

Part Three of our Microdosing Mushroom Series- Honest Discussion

Whenever anyone is thinking about trying a new product or service people tend to look for reviews.  In particularly honest reviews.  I can’t think of any person better to ask about microdosing mushrooms than Joe Rogan. He has been a very loud voice in the comedic community about the benefits of herbal medicine in particularly cannabis use. In this podcast Joe Rogan talks with Neal Brennan about the positive effects of microdosing mushrooms.

Brennan himself describes the positive effects that mushrooms have had for him, and Rogan references an MMA friend of his that uses microdosing as a way to enhance his fighting skills.

Check out the podcast: Joe Rogan & Neal Brennan on Micro-dosing Mushrooms  



What are the Benefits and Risks of Microdosing Mushrooms

What are the Benefits and Risks of Microdosing Mushrooms

I don’t want to oversimplify microdosing, so let’s go to the fine folks at Wikipedia for the official definition:

Microdosing, or micro-dosing, is a technique for studying the behaviour of drugs in humans through the administration of doses so low (“sub-therapeutic”) they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied.

Microdosing – Wikipedia 

Individuals typically take up microdosing for one of two different reasons: 1.  To decrease the frequency and intensity of undesirable mental states, or 2. To improve the frequency and intensity of desirable mental states.

This would lead us to conclude that microdosing may be a preferred treatment for someone suffering some sort of “mental illness” or mental distress. Microdosing would be an effective mood-altering treatment to stabilize someone who suffers from depression where it brings them to a more normal state.  Similarly, microdosing could be used as a treatment for combat veterans and first responders to bring them out of their hyper vigilant states and calm them down.

  Some of the mental illnesses that may benefit from microdosing would be:

  • Depression
  • Anxiety (i.e. Generalized or Social)
  • ADD/ADHD (Attention Deficit Disorder) 
  • Mood disorders
  • PTSD (Post Traumatic Stress Disorder)
  • Addiction

·       Studies are currently underway to see if the effects of using low doses of Psilocybin can be used to harness certain mental states that naturally occur in the brain.  For example, someone with chronic fatigue and low energy might use Psilocybin to attempt to influence the brain into a more energetic state, so that the individual feels more energized. An example of some of the desirable states or outcomes are:

  • Creativity
  • Energy
  • Flow states
  • Productivity/focus
  • Improved relationships/increased empathy
  • Athletic coordination
  • Leadership development

We’re not fond of the term “Mental Illness” because it pathologizes what is often a part of one’s natural progression towards a more coherent, actualized self.

But for those struggling with depression, anxiety, PTSD, ADD/ADHD, mood disorders and/or addiction (to name a few), microdosing can create a number of positive changes.

Clinical research has shown that larger doses of psychedelics are effective at treating depression, anxiety and addiction. Anecdotal evidence backs up the idea that a regular microdosing regimen can also have healing benefits for sufferers of various mental health conditions:

 Having said that, psychedelics are powerful substances, and even microdoses have a risk potential.

Emotional turbulence or anxiety is possible while microdosing, largely due to psychedelics’ ‘amplifying effect’. Psilocybin tends to amplify your current mood, rather than act as a stimulant or numbing agent. For this reason, it is important to assess your mindset before consuming a microdose.

Since Psilocybin Mushrooms have the potential to amplify your current mind state, we recommend discussing the risks with your physician if you suffer from psychosis, schizophrenia or severe anxiety, before you decide to begin microdosing. When overdone, microdosing can lead to manic states, which could exacerbate underlying conditions.

Since there is no clinical research on the safety of microdosing, it’s best to avoid microdosing for extended periods of time (longer than a few months). There is a potential heart risk of taking too many large doses of psychedelics over a long period of time – although we don’t know how this translates to microdosing.

Part One of this series




Mushroom Microdosing is a new and upcoming trend with recreational cannabis users.  Many psychedelic substances have been illegal for years, but most recently many of the world’s top experts have made many strides in research regarding psychedelics.

Much of what scientists know about psychedelics work involves serotonin, a chemical that keeps our brains ticking. It is one of the most important neurotransmitters in the brain and has an affect on nearly everything that we do everyday including what mood we are in, and how we process information.

According to the pharmaceutical industry, antidepressants typically to increase the production of serotonin in the brain so that a person feels better. Now psychedelics work a little more directly by copying or “mimicking” the effects of serotonin. This means that one of their main effects is to stimulate a serotonin receptor, located in the prefrontal cortex, called “5-HT2A.”

The stimulation of the 5-HT2A receptor leads to two very important results:

  1. The production of “Brain Derived Neurotrophic Factor” (BDNF). BDNF is “like Miracle-Gro for your brain. It stimulates growth, connections, and activity.”
  2. The increased transmission of “Glutamate.” Glutamate is the neurotransmitter most responsible for brain functions like cognition, learning, and memory.

Glutamate and BDNF work together in ways that science is still struggling to understand, but it’s become clear that having more of each leads to many of the benefits we all seek from “microdosing”.

Psychedelics allow unique connections to be formed by dampening the activity of an often over-used part of our brain called the “Default Mode Network”.

The Default Mode Network is an area of the brain used for an array of different mental activities, including day-dreaming, self-reflection, and thinking about the past or the future. Some studies suggest that depression is linked to an overactive DMN.  It’s possible that a highly active DMN causes us to ruminate, over-analyze ourselves, and step out of the present moment to constantly question the past and the future.

This helps explain why these substances could be used to combat depression and anxiety, and also lead to insights and creative perspectives that otherwise remain inaccessible to us.


What is a FLOW STATE?

All of us, at some point in our lives, have experienced a flow state. The surfer effortlessly riding a big wave, the therapist perfectly in-sync with her client, the salesman working the room in an out of body experience… all are examples of people performing at their best while in flow.

Simply put, flow is truly one of the great experiences of being human.

We have no specific, non-anecdotal evidence to suggest that microdoses of psychedelics can induce flow states – but we know that moderate doses can change the function of the brain in a way very similar to that seen in flow states.

Scientific studies show that moderate doses of psychedelics cause brain waves to shift more towards alpha oscillations, which is also seen in the transition to a flow state.

Psychedelics imitate the neurotransmitter serotonin when they enter the brain – and we know that serotonin is found in higher levels in flow states. Similarly, psychedelics increase the levels of dopamine in the brain,  another neurotransmitter which is found in higher levels in flow states.

Perhaps most importantly, psychedelics’ ability to dampen down the DMN can allow our brains to make unique connections between areas that don’t usually communicate. This is crucial for allowing flow states to occur.

Since we know that moderate doses of psychedelics can induce similar effects to a flow state in the brain, it seems likely that a regular microdosing regimen will start to shift our awareness in the direction of flow.

This is the first in a series of 5 articles explaining microdosing  and how it can be used to influence our moods and increase the state of our mood.